Review 2 of “A Multi-Source Profile of TAAR3P: trace amine associated receptor 3, pseudogene as an IDG Orphan G Protein-Coupled Receptor” (v4)

Summary

There is limited evidence of this pseudogene creating a functional transcript or protein. A major revision is needed to assess if this pseudogene leads to a protein.

Recommendation

Identify data sources and methods that determine if a pseudogene such as TAAR3P as an example leads to protein product. Any PPI data is likely related to the TAAR3 gene product and non-specific selection of the protein, inherent in antibody-driven experiments.

Revise with major focus on answering 'is this a functional gene/gene product before assessing downstream association.