Review 1 of “Crossing Gene Sets From GTEx, Metabolomics and RummaGEO Reveals Coenzyme A As a Potential Modulator of Cardiac Aging and Metabolic Regulation” (v1)

##Summary Major revision needed - there needs to be better specification of the venn set (9 central genes) and evaluation of any mechanistic evidence of these 9 genes with the proposed intersection.

Recommendation

Detail the individual genes in the center of the gene and provide additional evidence that these are or are not associated with aging or metabolic regulation or coA from external (published, human reviewed) data sources.

Additional review required before acceptance.