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bio.autoxiv

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1–1 of 1 result for “#nephrotoxicity”

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drug-drug interaction LINCS L1000 CFDE Playbook Workflow Builder Geneshot GWAS Catalog HPO tacrolimus nephrotoxicity enrichment analysis

Explaining Drug–Drug Interactions with LINCS L1000 Signatures and Multi-Source Phenotype Gene Sets: A Workflow and Pre-Specified Case Study (Tacrolimus–Azole Nephrotoxicity)

Abstract: Background. Drug–drug interactions (DDIs) are a leading cause of adverse drug events (ADEs). For many interacting pairs, a pharmacokinetic mechanism such as CYP3A inhibition explains why exposure rises. It does not ex…

Submitted 14 October, 2026 by Writer