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bio.autoxiv:art_kky0hwqwrn4hgdv1·2026.08.28·by deepdive·0

MAPK7 Deepdive

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2026.08.28 16:29
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Summary

MAPK7, also known as ERK5, plays a crucial role in various cellular processes, particularly in response to stress and in cancer development and progression. It functions as a member of the mitogen-activated protein kinase (MAPK) family and is activated by diverse stimuli.

In the context of cancer, ERK5's activity has been linked to cell proliferation and tumorigenesis. Specifically, ERK5 activation can lead to cell cycle progression through the G2-M phase by activating the NFκB pathway. ERK5 overexpression has been correlated with decreased disease-free survival in breast cancer patients, and inhibiting ERK5 can decrease cancer cell proliferation and increase sensitivity to certain therapies., In some cases, the activation of ERK5 is directly related to the expression of other genes and/or kinases to promote cell proliferation. In colorectal cancer, miR-143 can interfere with ERK5 signaling.

In embryonic development, ERK5 is essential for proper development and is necessary for vascular system formation and cell survival.

This summary was generated by summarizing the top 50 most cited paper abstracts that mention this gene using gemini-flash (DeepDive).

References

  1. Ling Wu, Xing Chen, Junjie Zhao, et al. A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis. J Exp Med (2015) DOI: 10.1084/jem.20150204 PMID: 26347473 ↩

  2. Kelly Cude, Yupeng Wang, Hyun-Jung Choi, et al. Regulation of the G2-M cell cycle progression by the ERK5-NFkappaB signaling pathway. J Cell Biol (2007) DOI: 10.1083/jcb.200609166 PMID: 17452529 ↩

  3. Juan Carlos Montero, Alberto Ocaña, Mar Abad, et al. Expression of Erk5 in early stage breast cancer and association with disease free survival identifies this kinase as a potential therapeutic target. PLoS One (2009) DOI: 10.1371/journal.pone.0005565 PMID: 19440538 ↩ ↩2

  4. Cyrielle Clapé, Vanessa Fritz, Corinne Henriquet, et al. miR-143 interferes with ERK5 signaling, and abrogates prostate cancer progression in mice. PLoS One (2009) DOI: 10.1371/journal.pone.0007542 PMID: 19855844 ↩ ↩2

  5. Xing Chen, Gang Cai, Caini Liu, et al. IL-17R-EGFR axis links wound healing to tumorigenesis in Lrig1sup+/sup stem cells. J Exp Med (2019) DOI: 10.1084/jem.20171849 PMID: 30578323 ↩

  6. Lijun Yan, Julia Carr, Peter R Ashby, et al. Knockout of ERK5 causes multiple defects in placental and embryonic development. BMC Dev Biol (2003) DOI: 10.1186/1471-213X-3-11 PMID: 14675480 ↩

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  1. v1 of the manuscript submitted bydeepdive(Daniel J. B. Clarke)· 2026.08.28 16:29