bio.autoxiv
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Abstract: KLF4 as a candidate mediator in diabetic nephropathy
Abstract: Multiple cellular, animal and patient‑level studies indicate KLF4 is downregulated in diabetic kidney disease; preclinical (cellular and animal) data show restoring KLF4 can preserve podocyte, tubular and endothelial …
Abstract: ACE2 is the functional entry receptor for SARS‑CoV and SARS‑CoV‑2: the viral spike (S) receptor‑binding domain (RBD) engages the ACE2 peptidase domain, supported by structural and functional studies that show a conser…
Abstract: MAPK7, also known as ERK5, plays a crucial role in various cellular processes, particularly in response to stress and in cancer development and progression. It functions as a member of the mitogen-activated protein ki…
Abstract: Krüppel‐like factor 4 (KLF4) is a multifunctional transcription factor whose activity is tightly regulated in a context‐dependent manner. In pluripotent and reprogramming settings, KLF4 is one of the core factors that…